Endocrine Abstracts

Introduction: The importance of highly sensitive screening tests for pheochromocytoma/paragnaglioma (PPGL) is clear. However, a low level of specificity may lead to unnecessary biochemical and imaging investigations and even to needless surgical procedures. Therefore, in patients with elevated values of metanephrines, it is essential to establish a rational threshold for performing prompt thorough diagnostic investigations rather than opting for active surveillance.<p clas...

BackgroundThe term adrenal incidentaloma (AI) refers to the existence of an asymptomatic adrenal mass that was detected at random in an imaging test performed not in order to evaluate the adrenal glands. In recent years, the use of imaging tests has increased, and the resolution of the imaging studies has been improved. This trend may affect the characteristics of AIs at the time of diagnosis.ObjectiveInvesti...

Context: Possible increased risk of malignancy in patients treated with denosumab has been concerned due to inhibition of the immune modulator receptor activator of nuclear factor κ-B ligand.Objective: To assess the risk of malignancy associated with denosumab treatment.Data Sources: PubMed and Cochrane Central Register of Controlled Trials were searched up to May 27, 2019.Study Selection: All randomized...

Introduction: The recognition that disease presentation, treatment and outcomes may differ betweenmen and women has become established. We have recently reported a-7.4% rate of denosumab-associated hypocalcemia in community-dwelling osteoporotic patients.Aim: To investigate the role of gender in this complication.Methods: A retrospective analysis of medical records (2010–2018) from a large HMO. An albumin-adjusted serum calci...

Background: The majority of adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas are less than 10 mm in diameter and are described as microadenomas, while corticotroph macroadenomas (≥10 mm) are a less common cause of Cushing’s disease. Prior reports on the differences of clinical and biochemical behavior of corticotroph microadenomas and macroadenomas were inconsistent.Objective: Describe the clinical and biochemical characteristic...

Background: Adrenocorticotropic hormone (ACTH)-producing pituitary adenoma is the most common cause of endogenous Cushing syndrome (CS), but the relative proportion of adrenal causes of CS is rising. Limited data are available on the clinical manifestations and cause of CS in older women.Objective: Determine the clinical presentation, biochemical profile, and cause of CS in women 65 years of age and older, compared with younger patients with CS.<p cl...

Introduction: Two aetiologies are responsible for postpartum hypopituitarism; Sheehan’s syndrome which develops following traumatic labour, and lymphocytic hypophysitis. Since management of lymphocytic hypophysitis does not require surgery in most cases, pathology is usually absent, and the clinical presentation, in combination with laboratory and imaging characteristics establish the diagnosis. We aimed to describe the various patterns of presentation, including assistin...

Introduction: Primary hyperparathyroidism (PHPT) is the third most common endocrinopathy. Data on PHPT in the elderly are scarce.Objective: To characterize elderly patients with PHTP, clinically and biochemically.Patients: A total of 216 patients (73.6% females) aged≥75 years were diagnosed and followed at a single tertiary medical center for PHPT.Results: Mean follow-up was 11.3±5.5 years. Age at ...